Pharmacotherapeutic group: Cytostatic - Antineoplastic drug.
Pharmacology: Mechanism of action: Navelbine is a cytostatic antineoplastic of the vinca alkaloid group. The molecular target of its activity is tubulin/microtubule dynamic equilibrium. Navelbine inhibits the polymerization of tubulin. lt acts preferentially on mitotic microtubules and affects axonal microtubules only at high concentration.
The effects on tubulin spiralization are Iower than with vincristine. Navelbine blocks mitosis in phase G2+M and induces cell death at interphase or at the following mitosis.